Internal Ribosome Entry Sites (IRES)
I wanted to know if an IRES was a linear sequence or an mRNA secondary structure. Technically, I should have assumed that a linear sequence might lead to a secondary structure (based on the laws of protein assembly) but I didn't. I looked it up:
IRES elements are highly structured cis-acting regions on the viral RNA. They serve as binding sites for proteins of the translational apparatus and facilitate the internal entry of ribosomes independently of the 5ยด-end of the viral RNA or a cap-nucleotide.
So this one mRNA was like, "you don't have to recognize my cap to sit down" and the ribosome was all like, "okay." Together, they made a completely different protein...
IRES elements are highly structured cis-acting regions on the viral RNA. They serve as binding sites for proteins of the translational apparatus and facilitate the internal entry of ribosomes independently of the 5ยด-end of the viral RNA or a cap-nucleotide.
So this one mRNA was like, "you don't have to recognize my cap to sit down" and the ribosome was all like, "okay." Together, they made a completely different protein...
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